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KMID : 0545119970070010049
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Journal of Microbiology and Biotechnology
1997 Volume.7 No. 1 p.49 ~ p.51
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Antifungal Activities of Magainin-2 Hybrid Peptides against Trichosporon beigelii
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Lee, Dong Gun
Shin, Song Yub/Lee, Sung Gu/Kim, Kil Lyong/Lee, Myung Kyu/Hahm, Kyung Soo
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Abstract
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In order to obtain a synthetic peptide with a more potent antifungal activity than magainin-2 but without hemolytic activity, four hybrid peptides were designed from the sequences of magainin 2 and cecropin A and their antifungal activities against Trichosporon beigelii were investigated. The result showed that analogue 2 and 4 exhibited better antifungal activity against T. beigelii than magainin-2 but no hemolytic activities. The peptides, therefore, could be used as models for the development of potent antifungal peptides.
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KEYWORD
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